SrasV1, Main, Exploration, bibRecord, 002F37

Determining SARS sub-clinical infection: A longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital

Identifieur interne : 002F37 ( Main/Exploration ); précédent : 002F36; suivant : 002F38

Determining SARS sub-clinical infection: A longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital

Auteurs : ZHEN YANG [République populaire de Chine] ; SHIXIN WANG [République populaire de Chine] ; QIAN LI [République populaire de Chine] ; YUMING LI [République populaire de Chine] ; MAOTI WEI [République populaire de Chine] ; HONGSHENG GAO [République populaire de Chine] ; Catherine Donovan [Canada] ; Peizhong Peter Wang [Canada, République populaire de Chine]

Source :

Scandinavian journal of infectious diseases [ 0036-5548 ] ; 2009.

RBID : Pascal:09-0309841

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Asymptomatique, Epidémiologie, Contrôle, Homme, Epidémie, Hôpital, Microbiologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Asymptomatic, Check, Epidemic, Epidemiology, Hospital, Human, Microbiology, Severe acute respiratory syndrome.

Abstract

A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61 % tested by ELISA and 0.21 % by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and were compared with a control population. Serum samples taken at various times were tested for IgG and IgM; dynamic serological changes in these antibodies were described. The positive responses of IgM and IgG antibodies in sera against SARS virus from the first week to the sixth week after onset of the illness in patients with SARS were measured. The ELISA test of IgG antibody was negative in 200 community controls. The positive rate in the SARS high-risk population was 0.61 % tested by ELISA and 0.21 % by IFA. The high-risk population in this study was defined as those who provided health care and other services to SARS patients during the outbreak. IgG antibody in convalescent serum of patients with SARS revealed an increasing trend, peaking at the 22nd week after onset of illness followed by a slow decline. IgM appeared earlier than IgG and can be better used for early detection. IgG remained at a high level for a much longer period, serving as a good indicator for follow-up and for assessing past exposure. Our results also suggest that sub-clinical infection, if it exists, is very rare.</div>
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Determining SARS sub-clinical infection: A longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital

Determining SARS sub-clinical infection: A longitudinal seroepidemiological study in recovered SARS patients and controls after an outbreak in a general hospital

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri